Publications – COP:TRIN

Publications

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Antibody responses and risk factors associated with impaired immunological outcomes following two doses of BNT162b2 COVID-19 vaccination in patients with chronic pulmonary diseases

Published July 2022 in BMJ Open Respiratory Research

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ERS statement: a core outcome set for clinical trials evaluating the management of COPD exacerbations

Published May 2022 in European Respiratory Journal

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The Impact of Social Distancing in 2020 on Admission Rates for Exacerbations in Asthma: A Nationwide Cohort Study

Published April 2022 in The Journal of Allergy and Clinical Immunology: In Practice

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Feasibility of randomizing Danish citizens aged 65-79 years to high-dose quadrivalent influenza vaccine vs. standard-dose quadrivalent influenza vaccine in a pragmatic registry-based setting: rationale and design of the DANFLU-1 Trial

Published February 2022 in Pilot and Feasibility Studies

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Lung ultrasound findings following COVID-19 hospitalization: A prospective longitudinal cohort study

Published February 2022 in Respiratory Medicine

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Hyperimmune immunoglobulin for hospitalised patients with COVID-19 (ITAC): a double-blind, placebo-controlled, phase 3, randomised trial

Published February 2022 in The Lancet

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Flu Vaccine and Mortality in Hypertension: A Nationwide Cohort Study

Published February 2022 in Journal of the American Heart Association

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Persistence and genetic adaptation of Pseudomonas aeruginosa in patients with chronic obstructive pulmonary disease

Published February 2022 in Clinical Microbiology and Infection

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Adrenal suppression in patients with chronic obstructive pulmonary disease treated with glucocorticoids: Role of specific glucocorticoid receptor polymorphisms

Published February 2022 in PLOS ONE

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Social distancing in relation to severe exacerbations of COPD – a nationwide semi-experimental study during the COVID-19 pandemic

Published January 2022 in American Journal of Epidemiology

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Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial

Published December 2021 in The Lancet Infectious Diseases

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Assessing Treatment Success or Failure as an Outcome in Randomised Clinical Trials of COPD Exacerbations. A Meta-Epidemiological Study

Published December 2021 in Biomedicines

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Management of COVID-19-Associated Acute Respiratory Failure with Alternatives to Invasive Mechanical Ventilation: High-Flow Oxygen, Continuous Positive Airway Pressure, and Noninvasive Ventilation

Published December 2021 in Diagnostics

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Long-term cognitive and pulmonary functions following a lower versus a higher oxygenation target in the HOT-ICU trial: protocol and statistical analysis plan

Published November 2021 in Acta Anaesthesiologica Scandinavica

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The Association between Use of ICS and Psychiatric Symptoms in Patients with COPD—A Nationwide Cohort Study of 49,500 Patients

Published October 2021 in Biomedicines

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ERS Statement: A core outcome set for clinical trials evaluating the management of chronic obstructive pulmonary disease (COPD) exacerbations

Published October 2021 in European Respiratory Journal

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Use of inhaled corticosteroids and risk of acquiring Pseudomonas aeruginosa in patients with chronic obstructive pulmonary disease

Published September 2021 in Thorax

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Biomarkers in Chronic Obstructive Pulmonary Disease: Emerging Roles of Eosinophils and Procalcitonin

Published August 2021 in Journal of Innate Immunity

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Treatment Response Biomarkers in Asthma and COPD

(Danish) Published September 2021 in Diagnostics

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Alpha-1-antitrypsin deficiency

(Danish) Published July 2021 in Ugeskrift for Læger

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Systemic Corticosteroids and the Risk of Venous Thromboembolism in Patients with Severe COPD: A Nationwide Study of 30,473 Outpatients

Published July 2021 in Biomedicines

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Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events: the ECHOVID-19 study

Published July 2021 in the Journal of Ultrasound

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Corticosteroid resistance in smokers – a sub study analysis of the CORTICO-COP randomised controlled trial

Published June 2021 in the Journal of Clinical Medicine

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Azithromycin and hydroxychloroquine in hospitalised patients with confirmed COVID-19–a randomised double-blinded placebo-controlled trial

Published June 2021 in the European Respiratory Journal

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Hydroxychloroquine as a primary prophylactic agent against sars-cov-2 infection: a cohort study

Published June 2021 in the International Journal of Infectious Diseases

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Risk of Chronic Obstructive Pulmonary Disease Exacerbation in Patients Who Use Methotrexate—A Nationwide Study of 58,580 Outpatients

Published May 2021 in Biomedicines

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Effect of different corticosteroid regimes for hospitalised patients with exacerbated COPD: pooled analysis of individual participant data from the REDUCE and CORTICO-COP trials

Published May 2021 in Respiratory Research

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Withdrawal of Inhaled Corticosteroids in Patients with COPD – A Prospective Observational Study

Published March 2021 in International Journal of Chronic Obstructive Pulmonary Disease

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Does inhaled corticosteroid use affect the risk of COVID-19-related death?

Published January 2021 in Breathe

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Antibiotic treatment in acute exacerbation of COPD: patient outcomes with amoxicillin vs. amoxicillin/clavulanic acid-data from 43,636 outpatients

Published January 2021 in BMC Respiratory Research

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Proactive prophylaxis with azithromycin and hydroxychloroquine in hospitalized patients with COVID-19 (ProPAC-COVID): a statistical analysis plan

Published October 2020 in Trials

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Bone turnover biomarkers in COPD patients randomized to either a regular or shortened course of corticosteroids: a substudy of the randomized controlled CORTICO-COP trial

Published October 2020 in the British Medical Journal

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Depressive symptoms among patientswith COPD according to smoking status: a Danish nationwide case–control study of 21184 patients

Published September 2020 in ERS Open Research

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TOB-STOP-COP (TOBacco STOP in COPdtrial): study protocol—a randomized open-label, superiority, multicenter, two-arm intervention study of the effect of“high-intensity”vs.“low-intensity”smokingcessation intervention in active smokerswith chronic obstructive pulmonary disease

Published August 2020 in Trials

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Proactive Prophylaxis With Azithromycinand HydroxyChloroquine in HospitalisedPatients With COVID-19 (ProPAC-COVID):A structured summary of a study protocolfor a randomised controlled trial

Published June 2020 in Trials

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Roflumilast in Severely Ill Patients With Chronic Obstructive Pulmonary Disease With Frequent Exacerbations: Risk of Pneumonia Hospitalization and Severe Exacerbations

Published May 2020 in Journal of Clinical Medicine

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Use of inhaled corticosteroids and the risk of developing type 2 diabetes in patients with chronic obstructive pulmonary disease

Published April 2020 in Diabetes, Obesity & Metabolism

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Pseudomonas aeruginosa and risk of death and exacerbations in patients with chronic obstructive pulmonary disease: an observational cohort study of 22 053 patients

Published February 2020 in Clinical Microbiology and Infection

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Antibiotic treatment adequacy and death among patients with Pseudomonas aeruginosa airway infection

Published December 2019 in PLoS One

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Hot topics on procalcitonin use in clinical practice, can it help antibiotic stewardship?

Published December 2019 in Internation Journal of Antimicrobial Agents

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Physiological abnormalities in patients admitted with acute exacerbation of COPD: an observational study with continuous monitoring

Published November 2019 in Journal of Clinical Monitoring and Computing

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Non-eosinophilic severe exacerbations of COPD: what about antibiotics?

Published November 2019 in The Lancet Respiratory Medicine

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Procalcitonin in acute infections: from the research laboratory to clinical impact—new perspectives of biomarker use

Published October 2019 in Journal of Laboratory and Precision Medicine

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Biomarkers of Acute Lung Injury The Individualized Approach: for Phenotyping, Risk Stratification and Treatment Surveillance

Published August 2019 in Journal of Clinical Medicine

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Eosinophil-guided corticosteroid therapy in patients admitted to hospital with COPD exacerbation (CORTICO-COP): a multicentre, randomised, controlled, open-label, non-inferiority trial

Published May 2019 in The Lancet Respiratory Medicine

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Biomarker-assisted identification of sepsis-related acute liver impairment: a frequent and deadly condition in critically ill patients

Published March 2019 in Clinical Chemistry and Laboratory Medicine

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COPD exacerbations: the impact of long versus short courses of oral corticosteroids on mortality and pneumonia: nationwide data on 67 000 patients with COPD followed for 12 months

Published March 2019 in British Medican Journal Open Respiratory Research

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Procalcitonin (PCT)-guided antibiotic stewardship: an international experts consensus on optimized clinical use

Published December 2018 in Clinical Chemistry and Laboratory Medicine

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Automated oxygen control with O2matic® during admission with exacerbation of COPD

Published December 2018 in Internation Journal of Chronic Obstructive Pulmonary Disease

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Acute Lung Injury in Critically Ill Patients: Actin-Scavenger Gelsolin Signals Prolonged Respiratory Failure

Published September 2019 in Shock

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Danish respiratory society position paper: palliative care in patients with chronic progressive non-malignant lung diseases

Published October 2018 in European Clinical Respiratory Journal

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Procalcitonin-guided antibiotic treatment in patients with positive blood cultures: A patient-level meta-analysis of randomized trials

Published July 2019 in Clinical Infectious Diseases

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Procalcitonin-guided antibiotic therapy algorithms for different types of acute respiratory infections based on previous trials

Published July 2018 in Expert Review of Anti-Infective Therapy

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Sepsis: Personalized Medicine Utilizing ‘Omic’ Technologies—A Paradigm Shift?

Published September 2018 in Healthcare

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Forced fluid removal in intensive care patients with acute kidney injury: The randomised FFAKI feasibility trial

Published August 2018 in Acta Anaestesiologica Scandinavia

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Fluid accumulation during acute kidney injury in the intensive care unit

Published July 2018 in Acta Anaestesiologica Scandinavia

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Cytomegalovirus Viral Load in Bronchoalveolar Lavage to Diagnose Lung Transplant Associated CMV Pneumonia

Published February 2018 in Transplantation

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Induced hypothermia in patients with septic shock and respiratory failure (CASS): a randomised, controlled, open-label trial

Published January 2018 in The Lancet Respiratory Medicine

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Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis

Published October 2017 in The Lancet Infectious Diseases

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