Ongoing COPD trial: The COPERNiCOS trial
We are currently running a trial with the aim to determine if a time-updated, eosinophil-guided inhaled corticosteroid treatment in patients with severe and very severe COPD can lead to non-inferior treatment responses to standard treatment with combined ICS, LAMA and LABA, and whether the side-effects of ICS can be reduces by this guided administration. Furthermore, whether the use of azithromycin can reduce the time hospitalized with AECOPD (or other cause) in severe COPD patients.
Completed COVID-19 trial: The ProPac-COVID trial
We have completed a trial with the hypothesis that in patients who are urgently admitted and who have a positive test for 2019-nCoV and symptoms similar to COVID-19 disease, treatment with corona virus inhibitor hydroxychloroquine as well as virus-immunomodulatory and antibacterial drug azithromycin can lead to shorter hospitalisation and fewer admissions in the intensive care unit. Results were neutral in all outcomes.